Women who are significantly overweight have been found to be at higher risk of being in this 3%. Even after 10 weeks there is a chance that they will not be able to collect enough cfDNA to provide a result. Before this it is difficult to collect enough cell-free DNA (cfDNA) from the blood sample. NIPT can be performed from 10 weeks of pregnancy. Future Health NIPT (Future Health Biobank).Ninalia and PrenatalSAFE (Eurofins Biomnis).Lucina NIPT (NHS West Midlands Regional Genetics Laboratory, Birmingham).The Maternit21 Plus Prenatal Test (Labscorp).The IONA Test and SAFE Test (Yourgene Health).You should be able to find this on their websites. One way to check their claims is to look at the published data* they have on their test performance. They all claim high detection rates but some differ in the way they analyse the cfDNA. You can find out more about the labs doing the analysis below. There is no ‘direct to consumer’ testing available it must be done via a health care professional. Individual clinicians and private clinics are offering NIPT provided by a number of different laboratories, based here and overseas. NIPT was implemented in Wales in April 2018, in Scotland in September 2020 and in England in July 2021. In 2016, after a detailed review of the international evidence and a public consultation, the UKNSC recommended that NIPT should be carefully implemented into the NHS as part of the current Fetal Anomaly Screening Programme, (to be offered only to those women who have a screening result between 1 in 2 to 1 in 150). So it is currently a very sensitive screening test for Down’s syndrome, and it can also look for Edwards’ and Patau’s syndrome, though it is not as reliable for these two conditions. However, large scale studies show that the test has a high detection rate for Down’s syndrome. It is important to know that NIPT does not give a yes/no answer about chromosomal conditions. Most of the DNA comes from the mother but a small amount comes from the baby’s placenta. The blood sample is sent to a laboratory and cell-free DNA material is extracted and analysed. Non-invasive prenatal testing (NIPT), which is also known as cell-free DNA screening has been available (mainly in the private sector) in the UK since 2012.
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